Author Archives: pisrt

Abstract:The study aimed to investigate the impact of sleep on daily activities, academic performance, and various factors influencing sleep quality. The Pittsburgh Sleep Quality Index (PSQI) scale was used to collect data from 171 randomly selected medical students. Descriptive and inferential statistical analyses were performed to analyze the data. Results revealed that 40.9% of the study subjects had poor sleep quality, while 59.1% had good sleep quality. No significant association was found between sleep quality and socio-demographic factors or habits. However, statistically significant associations were observed between sleep quality and academic performance indicators, such as feeling of not doing enough, unsatisfactory results, and failing in exams. The study emphasizes the importance of adequate sleep for medical students given their demanding academic and professional roles and suggests that poor sleep quality can negatively impact academic performance. The prevalence of poor sleep quality among medical students may vary across countries due to differences in sample methods, academic stress levels, and social environments. Overall, the findings highlight the need to address sleep-related issues among medical students to improve their well-being and academic success. Further research is required to better understand the complex relationship between sleep quality, gender, socio-demographic factors, and psychological variables.

Abstract:Background: Osteoarthritis (OA) is a degenerative joint disease that affects the cartilage and surrounding tissues. This study aimed to compare the efficacy of oral native collagen type 2 and oral glucosamine sulphate in patients with grade 2 and grade 3 primary knee osteoarthritis.
Materials and Methods: This was a randomized observational prospective study conducted on patients aged 30 years or above, of any gender, diagnosed with primary knee osteoarthritis of grade 2 and 3. The patients were randomly assigned to two groups using computer randomization software. Group 1 received native type 2 collagen 40 mg (Tablet Dupact 40 mg, Wockhardt Limited), while Group 2 received oral glucosamine 1500 mg (Lubrijoint 750 mg twice daily).
Results: The majority of participants in the Glucosamine group were in the 51-60 years age group (32.5%), while the majority in the Collagen group were slightly younger, belonging to the 41-50 years age group (30%). The mean age of the Glucosamine group (57.2 \(\pm\) 10.45 years) was similar to the Collagen group (57.2 \(\pm\) 11.39 years), and the difference was not statistically significant. The pre-treatment and post-treatment (after 12 weeks) C-reactive protein (CRP) values did not show a statistically significant difference between the two groups. However, both the Glucosamine and Collagen treatments resulted in a significant reduction in WOMAC score and visual analog scale (VAS) score over the course of the 12-week treatment.
Conclusion: Both Glucosamine and Collagen treatments showed improvements in reducing painful and swollen joints, as well as significant improvements in VAS and WOMAC scores.

Abstract:Background: Intertrochanteric and subtrochanteric fractures are typically treated with proximal femoral nails. Proximal femoral nails come in two types: regular PFN (which consists of 2 proximal screws) and PFNA2 (which consists of a single proximal screw).
Aim: The aim of our study is to compare functional outcomes and implant-related complications in patients treated with regular PFN versus PFNA2 for intertrochanteric and subtrochanteric fractures.
Material and Methods: A prospective observational and randomized study was conducted with a total of 40 patients with intertrochanteric and subtrochanteric femoral fractures admitted to Bhaskar Medical College Hospital. After fulfilling the inclusion criteria, the patients were divided into two groups randomly, with 20 cases in each group. They were treated with regular PFN and PFNA2, respectively.
Conclusion: Based on the study, we concluded that PFNA2 reduces surgery time, blood loss, and radiation exposure compared to regular PFN. PFNA2 also has a higher union rate with significantly better functional outcomes compared to regular PFN. Patients treated with PFNA2 can bear weight early. Implant-related complications such as screw backing out and cut-through of screws in the femoral head (z-effect and reverse z-effect) are not observed with PFNA2. Therefore, we conclude that PFNA2 is superior to regular PFN.

Abstract:Background: Infected non-union and gap non-union are challenges that orthopaedic surgeons have to face globally. The open fracture is the most common cause of infected nonunion and tibia is the most commonly involved bone in the infected nonunion. In Ilizarov technique, vascularity is increased by corticotomy and application of a circular external fixator. It also provides micro motion due to distraction and gives an excellent biological environment for fracture healing.
Material and Methods: Seventeen consecutive patients with infected nonunion of long bones were treated from 2012 to 2016. The age range was 20 to 65 year-old male patients. Five cases were admitted with femoral infected non-union and twelve with septic non-union of tibia. Patients were followed up for one year. The predominant bacteria were Staphylococcus aureus and Pseudomonas aeruginosa. Average duration of antibiotics treatment was 4.9 (range, 2-6) weeks. The outcome measures were according to the classification of ASAMI, which is based on radiological (defect filling) and clinical (functional) findings.
Results: The cases were followed with mean period of 3.5 years (range, 2-5 years). In the present study, seventeen cases with septic non union of tibia and femur were evaluated. All cases completed treatment and achieved bony union with no signs of infection. In the present study, bone union result as per ASAMI score was excellent in 76.5%, good in 23.5% cases, and also the functional results were excellent in 76.5%, good in 23.5% cases. No patient had gone for amputation in our study.
Conclusion: Ilizarov technique has been a successful treatment for infected long bone non unions of tibia and femur associated with bone loss. Our results were similar with the existing literature about the study. The lengthy treatment time and considerable number of complications must be fully understood both by the surgeon and the patient before undertaking the ilizarov treatment method.

Abstract:Background: Breast cancer is the most common malignancy among women worldwide. According to the GLOBOCAN 2020 estimates of cancer incidence and mortality, female breast cancer has surpassed lung cancer and is now the most commonly diagnosed cancer, with an estimated 2.3 million new cases. In India, breast cancer has moved from being the fourth most common cancer in the 1990s to the first. The prevalence of established hormonal and reproductive risk factors is higher in Western countries, but these risk factors are not commonly observed in the rural population of India. Therefore, it is important to study the probable risk factors in our population, including the potential role of obesity, especially in postmenopausal women, in the development of breast cancer.
Aim and Objectives: The aim of our study is to determine the demographic profile of breast cancer patients and identify any associated risk factors for breast cancer in this population.
Methods: This analytical cross-sectional study was conducted at Alluri Sita Rama Raju Academy of Medical Sciences (ASRAM) over a period of one year from March 2021 to February 2022. We included 72 patients with histologically proven breast carcinoma who attended the Oncology OPD and met the inclusion criteria.
Results: In our study, approximately 86% of breast cancer patients had a body mass index (BMI) greater than 23. Obesity is known to be associated with increased estrogen levels, which can be a risk factor for hormonal-dependent breast cancer. Among the study group, 52% were luminal positive, 25% were triple negative, and 22.2% were HER2 neu positive.
Conclusion: Our study found that approximately 86% of breast cancer patients were obese. The association between BMI and breast cancer needs to be further studied in randomized control trials. Furthermore, reproductive and hormonal risk factors were not significantly observed in our population group.

Abstract:Background and Aims: Ventilator associated pneumonia (VAP) develops after more than 48 hours of mechanical ventilation. VAP is the leading cause of death among hospital acquired infection and prolongs time spent on the ventilator, length of intensive care unit (ICU) stay and length of hospital stay after discharge from the ICU. The concept of ‘bundles’ which can be defined as groups of evidence based interventions when, performed together, improve outcome. Hence this study was undertaken to assess the incidence of VAP and effectiveness of Bundle to prevent VAP.
Methods: This study was conducted in two phases. Pre-interventional phase (Phase-1) is done for three months by observing the current practices in mechanically ventilated patents and assessing the incidence of VAP. Then in post-interventional phase is conducted for three months by applying the bundle care approach, educating the interns, staff nurses and contact care givers regarding the quality improvement project and then assessing the incidence of VAP.
Results: Total 40 patients were involved in the study with 20 patients in each trial. The incidence of VAP was more in pre-interventional trial and the VAP incidence was reduced in post-interventional trial after implementing bundle care.
Conclusions: VAP prevention can be achieved to a large extent with the use of Bundle care approach .However, a major limitation is the lack of adherence to the set protocols by the health care professional especially in developing countries like India where the still the Patient to Nurse ratio is poor and overworked doctors . But one of the way to improve is by educating them through targeted training and using checklist which will help to improve adherence and ultimately patient outcome.

Abstract:Objective: The objective of this study was to compare the effects of single intra-articular platelet-rich plasma (PRP) and corticosteroid (CS) injections in patients diagnosed with adhesive capsulitis of the shoulder.
Design: Patients between the ages of 30-70 years, of either sex, diagnosed with adhesive capsulitis of the shoulder with a duration of less than 6 months, were included. In the intra-articular corticosteroid (IA-CS, control) group, 30 patients received a single injection of IA-CS (2 ml), while in the IA-PRP (test) group, 30 patients received a single IA-PRP injection (2 ml) into the glenohumeral joint under ultrasound guidance. All patients were prospectively followed for 24 weeks.
Results: Thirty patients in the IA-PRP group and thirty in the IA-CS group completed the entire 24-week study period. At 24 weeks, a decrease in QUICK DASH score was observed in the IA-PRP group (16) compared to the IA-CS group (33). In terms of range of movement, the IA-PRP group showed significant improvement in abduction, internal rotation, and external rotation compared to the IA-CS group. No major complications were observed in any patients.
Conclusions: At the 24-week follow-up, a single dose of IA-PRP injection was found to be more effective than an IA-CS injection in improving pain, disability, and shoulder range of motion in patients with adhesive capsulitis of the shoulder.

Abstract:Overview: Cancer poses a significant global threat\({}^{1}\). Lymph nodal metastasis is a crucial prognostic factor, and its detection presents a challenge for pathologists.
Aims: The aims of this study are as follows: to determine the common sites affected by metastatic lymphadenopathy, to evaluate the effectiveness of the cell block technique in preserving cell morphology compared to conventional fine needle aspiration (FNA) samples, to assess the preservation of immunohistochemical properties using the cell block technique, and to determine the role of immunohistochemistry in cell block preparations of malignant breast neoplasms for making a final diagnosis.\\
Materials and Methods: Immunohistochemistry using AE1 and AE3 markers was performed on sections made from cell blocks obtained through the fine needle aspiration technique. Cell block preparation involved a mixture of 9 parts ethyl alcohol and 1 part 10% formalin, followed by hematoxylin and eosin staining. Two pathologists independently analyzed H&E-stained smears and immunocytochemistry results, and the findings were calculated.
Results: In the present study, pan CK positivity was observed in 31 out of 48 cases, of which 25 were squamous cell carcinomas, 2 were suspicious for malignancy, and 2 were other cases.
Conclusion: The use of Pan CK (AE1/AE3) markers demonstrated a significant percentage of positivity in identifying squamous differentiation. This panel of markers, along with others, can be employed for epithelial differentiation and can assist in neoadjuvant therapy and patient care.