Hyperhomocysteinemia and paediatric stroke: A case series

TCMS-Special issue: Recent developments of medical and surgical research (2023), pp. 584 – 588 Open Access Full-Text PDF
Anuja Sonika, Kinikar Utkarsha S and Dhanawade Sara S

Abstract:Background: Cerebrovascular disease in children is a rare occurrence with an annual incidence of 2.7/100,000 children. There are limited reports revealing stroke in pediatric population associated with hyperhomocysteinemia. We present a series of cases discussing the clinicolaboratory, radiological findings and management of children presenting with hyperhomocysteinemia and stroke.
Aim and Objective: To study the clinicolaboratory profile, radiological findings and outcome of children with hyperhomocystienemia and stroke.

Methodology: This is a retrospective observational study where case records of paediatric patients (<18 years) who had stroke associated with Hyperhomocysteinemia were studied. Over the last five years, seven were diagnosed with hyperhomocystienemia associated with paediatric stroke.
Results: Out of the seven patients, six of them presented with headache and hemiparesis, one presented with convulsions. Mean age of presentation was 9 $\pm$1.5 years. Neuroimaging in all suggested acute cerebrovascular infracts. All had elevated homocysteine levels and five had documented low vitamin B12 levels. MTHFR gene was positive in one patient. Bilateral lens dislocation was observed in three of them. Intellectual disability was observed in four of these patients, and marfanoid features were seen in three of them. All the patients were started on low dose aspirin and polyvitamin therapy. Four patients had complete recovery, one is still improving and one was lost to follow up. Recurrence was observed in one patient.
Conclusion: Commonest symptoms were headache and hemiparesis. Manifestations of hyperhomocysteinemia can start in infancy. Homocystiene estimation should be included in work up of paediatric stroke and polyvitamin therapy should be included in management.
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Evaluate the improvement in post-operative quality of life of incisional hernia patients repaired by conventional ventral hernioplasty with regards to physical pain, Functional ability and cosmesis

TCMS-Special issue: Recent developments of medical and surgical research (2023), pp. 576 – 583 Open Access Full-Text PDF
Saroj Kumar and Rakesh Kumar Verma

Abstract:Background: Incisional hernia (IH) is a frequent complication of open abdominal surgery. Patients with Incisional hernia present with symptoms such as pain, discomfort, limitation of routine activities, skin problems, strangulation of hernia content etc. It is one of the most frequent long-term complications of abdominal surgery and it continues to be a significant problem for patients as well as surgeon.
Methodology: The study was conducted at R. G. Kar Medical College & Hospital; Department of General Surgery. 50 elective patients having ventral hernia who have undergone conventional open ventral hernioplasty were included in the study. All the patients were given a Questionnaire initially in the pre-operative stage and subsequently in the 1st and 7th post-operative day and later on during 1st month and 6th months of post-operative follow up.

Results: In our study pain was the major concern of the incisional hernia patients. Initially 14% of patients were free of pain and rest 86 % were symptomatic for some pain. 14% out of these were having severe pain preoperatively. At one-month post-operative follow up in our series 11 (22%) remained symptomatic for mild to moderate pain. After 6 months of follow up number of patients having pain remains approximately the same. 11(22%).
Conclusion: By 6 months, postoperative symptoms (pain, activity limitation, and overall QOL) are significantly better when compared with preoperative findings and 1-month follow-up levels.
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Prevalence of nasal colonization of MRSA in a teaching hospital

TCMS-Special issue: Recent developments of medical and surgical research (2023), pp. 569 – 575 Open Access Full-Text PDF
Mamatha P Samaga, Sahana Shetty N S and Keerthi A M

Abstract:Background: MRSA is one of the leading causes of infections among hospitalized patients. The present study was conducted to know the prevalence of nasal colonization of MRSA in hospitalized patients.
Methodology:

Study design: A cross sectional study.
Study setting: Department of Microbiology, MIMS, Mandya, and
Source of data: Inpatients of MIMS teaching hospital, Mandya irrespective of any departments.
Method of collection of data: A proforma was used to record information on the Socio Demographic factors of the subjects including age, sex, presence of chronic disease, hospitalization within the previous year, use of antibiotics prior to a month of the sample collection, pattern of routine hygienic practices of the subjects. A total of 300 subjects were screened for MRSA after obtaining informed written consent from the subjects.
Results: Out of 300 Inpatients, 148(49.3%) were culture positive for Staphylococcus aureus,52 (17.3%) were MRSA carriers, Out of 52 MRSA isolates from Inpatients, all the 52(100%) isolates were sensitive to Vancomycin and Linezolid. 34(65.3%) were sensitive to Gentamicin, 24(46.1%) to Tetracycline, 23(44.2%) to Ciprofloxacin and 19(36.5%) to Chloramphenicol. All the 52(100%) isolates were resistant to Penicillin followed by 39(75%) resistance to Clindamycin, 38(73.07%) to Erythromycin and 33(63.5%) to Chloramphenicol.
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Study of tibial ACL footprint in patients undergoing ACL reconstruction-correlation between pre-op MRI and intra-op measurements using arthroscopic ruler

TCMS-Special issue: Recent developments of medical and surgical research (2023), pp. 562 – 568 Open Access Full-Text PDF
Nandeesh S, Ambrish Sharma, Raju K P and Sumit Kumar

Abstract:Background: Currently measuring the preoperative size of the ACL tibial footprint. Length on sagittal MRI view is measured as the most anterior and most posterior portion of the ACL tibial attachment. To have an accurate measurement for the size of an ACL footprint, the ability to accurately identify the insertion site on MRI is important.
Methodology: 20 patients with ACL tear were included in the study.
Results: The mean age of the study participants was found to be 29.35+6.507 years. The mean weight of the study participants was found to be 75.55+12.84. The mean pre-op Tibial footprint of the study participants was found to be 12.54+2.24. The mean intra-op Tibial footprint of the study participants was found to be 12.87+1.53. The correlation was found to be statistically significant between the pre-op findings and the intra-op findings.
Conclusion: Tibial foot print length measured preoperatively on MRI can be used as a strong predictor for actual tibial length which can be helpful for prior planning of ACL reconstruction to improve the outcome.

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Awareness about HIV/AIDS amongst urban deaf adolescents and comparing it with normal adolescent population

TCMS-Special issue: Recent developments of medical and surgical research (2023), pp. 558 – 561 Open Access Full-Text PDF
Ashlesha Ashok Tawde and Prasad Waingankar

Abstract:Background: Among the greatest risk factors affecting deaf people is a general lack of knowledge about HIV/AIDS and its prevention. Studies found that deaf people are frequently unaware of or are misinformed about how AIDS is transmitted, how it can be prevented and who can get it.
Aims and Objectives: To study awareness about HIV/ AIDS amongst Urban deaf Adolescents and comparing it with normal Adolescent population.
Methodology: This was a cross-sectional study among the deaf adolescents and normal adolescents with respect to HIV/ AIDS amongst Urban population during the one month period i.e. March 2017. adolescents (10-19 Yrs.) students in the schools for Deaf selected randomly 100 and in the Normal adolescents students selected randomly 100 of a urban area were taken into the study. All the students with the written explained consent were undergone a semi-structured written questionnaire regarding the modes and prevention of HIV / AIDS was asked, there responses were noted, tabulated in the excel sheets and analyzed by SPSS 19 version software.
Result: The significantly lower awareness with respect to the modes of transmission like Mosquito bites (p<0.05), Sex in man to man (p<0.05), Kissing (p<0.05), Touching or hugging (p<0.05), Germs in the air (p<0.05), Unsterilized razors, HIV+ve mother to baby, Use of public toilets (p<0.05) respectively. There was significantly lower awareness regarding the prevention of HIV/AIDS was lower in Deaf adolescents e.g. Avoiding dirty places, Not hugging, Abstinence, Yoga and Meditation (p<0.05).
Conclusion: It can be concluded from our study that the deaf adolescent were significantly the knowledge and having misbelieves regarding HIV/ AIDS may be lack of education or lack communication and hence are at more risk of transmission than the general adolescent population.

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Clinical profile of children with COVID-19 Admitted at KIMS Hospital, Bangalore- A prospective study

TCMS-Special issue: Recent developments of medical and surgical research (2023), pp. 553 – 557 Open Access Full-Text PDF
Ramya H S, Afroza Asiya, Aks Sultan Thariani and Kavya VN

Abstract:Background: Children account for a small percentage of laboratory confirmed COVID-19 cases, with the clinical course different from the adults. The number of COVID positive cases increased from May 2020. It has been a challenge for clinicians worldwide to manage and treat COVID-19 affected patients, given the meagre information we have regarding the clinical course and the treatment protocols available.
Purpose: The purpose of this study is to analyze the clinical spectrum and outcome in children admitted with COVID-19.
Methods: This is a prospective study of children admitted to KIMS-Bangalore with confirmed COVID-19. In all cases patient demographics including history of exposure, symptoms, age, sex, address were obtained upon admission and laboratory findings were obtained from hospital records.
Results: in our study, 50 children were admitted to KIMS, bangalore. Contact history was found in 80% of the children. 20% were symptomatic without contact history. 54% children were asymptomatic, 46% were symptomatic. Of the symptomatic children, 54% had mild (with fever), 36% had moderate (fever with cough) and 8% had severe symptoms (fever, cough and breathlessness), cases between 6-12 years were –% with a slight female preponderance(54%). None of the children had known comorbid conditions. Oxygen dependency was found in 20% children. COVID was severe in 2 cases (4%), with secondary infection. No deaths were noted in our study.
Conclusion: The course of the disease in children was mild to moderate when compared to adults with no mortality. This is due to underdeveloped immune system, which have not affected the children in large extent. Asymptomatic cases have lead to underdiagnosis of COVID-19 in children, resulting in their becoming silent convalescent carriers and causing disease spread and increase in case load. Hence, it is of utmost importance that children be taught preventive measures such as usage of mask, hand hygiene by using soaps and sanitizers, avoid touching of surfaces and maintaining social distance with elderly persons in the family and surroundings. Upcoming vaccines to children are promising in ending COVID-19 pandemic.

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The role of the non-stress test as a method to evaluate the outcome of term pregnancy at a tertiary care hospital in India

TCMS-Special issue: Recent developments of medical and surgical research (2023), pp. 549 – 552 Open Access Full-Text PDF
Aishwarya Ghogare, Sujata Pavan Jadhav, Pavan Pralhadrao Jadhav and Swati Nagapurkar

Abstract:Background: The non-stress test is the most widely used test for the assessment of fetal health and reflects oxygenation of the brain. Fetal movements during testing are identified by maternal perception and are recorded. NST is based on the hypothesis that the heart rate of a fetus who is non-acidotic, non- impaired will temporarily accelerate in response to fetal movements. The fetal heart rate normally is increased or decreased by autonomic influences mediated by sympathetic or parasympathetic impulses from brain stem centers. NST uses minimum thresholds of FHR acceleration frequency to distinguish healthy from compromised fetuses. The value of “reactivity” or accelerations associated with fetal movement may vary considerably with the composition of the population tested, gestational age, the frequency of test repetition, and the use of other baseline FHR features in the evaluation of the test.
Methodology: The study was conducted at Department of OBGY in a tertiary care hospital in India for a duration of one year. 100 pregnant woman with pregnancy from 37 weeks to 42 weeks of gestation were included in the study. The electronic fetal monitor is used for NST. The NST was categorized as Reactive and Non -Reactive. Reactive In a 20-minute period, two or more fetal heart rate accelerations of at least 15 beats per minute above the baseline heart rate. If the NST came out to be non-reactive, NST was repeated for another 20 minutes and if it still remained Non- reactive then Biophysical profile was done for that patient and the decision was taken according to the result of the biophysical profile score.
Results: The mean age of patients was 26.72\(\pm\)4.58 years. Out of 100 NST, -67 (67%) NST were reactive while 23 (23.18%) were non-reactive. Women admitted with reactive NST had significantly higher vaginal delivery rates i.e. (42% vs. 14%). Operative delivery in non -reactive NST group was significantly higher than the reactive NST group, i.e., (86% vs. 58%). All 100 babies were born alive irrespective of the NST status and 13% (13) required NICU admission. The individual parameters of poor fetal outcome like meconium stained liquor, Apgar score <7 at 5 minutes had increased incidences in the non-reactive group.
Conclusion: The “NST at admission” is a straightforward and uncomplicated procedure for determining the fetal status antenatally. Its responsiveness ensures a positive outcome for both the mother and the fetus, while non-responsiveness raises the risk of operative delivery and NICU hospitalization.

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Clinical profile of rhino-orbito-cerebral mucormycosis cases during second wave of COVID-19 pandemic presenting to tertiary care Hospital-A retrospective study

TCMS-Special issue: Recent developments of medical and surgical research (2023), pp. 539 – 548 Open Access Full-Text PDF
Dorkar Shashikant Narayan, Nilakhe Sachin Sharad and Panchal Shivani Bhagwatkumar

Abstract:Background: A retrospective study of records of 113 patients presenting to a tertiary care hospital during the 2nd wave of the COVID-19 pandemic was carried out with an aim to study the clinical profile of rhinoorbitocerebral mucormycosis (ROCM) patients.
Results: Out of 113 patients, 80 were males and 33 were females with a male-to-female ratio of 2.42:1. The most common age group affected was 51-60 years for both males (n=24) and females (n=37). The most common clinical presentation was headache (n=80) followed by ptosis, proptosis, and ophthalmoplegia (n=77). Based on radiology, all patients had nose and paranasal sinuses involvement, 71.68% had orbital involvement, and 13.27% had intracranial involvement. The most common extrasinus involvement was maxillofacial soft tissue. 89% were either COVID positive or COVID like on HRCT or post-COVID. Only 11% had no history of COVID or COVID like on HRCT (High Resolution Computed Tomography). 83 were diabetic, 55 had kidney disease, and 38 were hypertensive. 45.13% of patients had a history of steroid use, 21.23% had used oxygen, and 4.42% had a history of ventilator support.
Conclusion: Mucormycosis is a multi-system fungal infection with a significant surge in incidence in the second wave COVID era, which suggests a possible correlation of COVID infection with mucor. Uncontrolled diabetes is the commonest risk factor for mucor infection. The disease primarily involves the nose and paranasal sinuses, extending to the surrounding areas. MRI with contrast is the gold standard diagnostic modality to define the disease extent. Retromaxillary fissure involvement is an important cause for ophthalmoplegia in the majority of patients. Limited endoscopic orbital debridement with preservation of the globe avoids gross disfigurement and mental trauma to the patients. Early diagnosis with aggressive anti-fungal treatment combined with surgical debridement results in improving overall prognosis and survival in post-COVID mucormycosis patients.

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Compare the effectiveness of Epley’s Manouvre and Brandt Daroff’s exercise in relieving vertigo in patients with BPPV

TCMS-Special issue: Recent developments of medical and surgical research (2023), pp. 534 – 538 Open Access Full-Text PDF
Nirmala Maruthi and Jagannatha Bisanna

Abstract:Background: Benign Paroxysmal Positional Vertigo is the most frequent vestibular disorder characterized by brief episodes of vertigo caused by changes in the position of a person’s head. It significantly affects the quality of life of elderly patients by interrupting their daily activities.
Methodology: The study was conducted at the Department of E.N.T, Kempegowda Institute of Medical Sciences. Sixty patients who fulfilled the inclusion criteria were included in the study. Patients were evaluated through proper history taking using a proforma and clinical examination. The Dizziness Handicap Inventory scoring system was used, and baseline (pre-treatment) scores were recorded. Patients were asked to come back after 3 weeks for follow-up (post-treatment) and then after 3 months for further follow-up.
Results: The mean age of subjects in the Epley’s manoeuvre group was 43.60 years, while it was 40.97 years in the Brandt Daroff’s exercise group. Among skilled workers in this study, tailors were most often affected, and the vibration associated with their work may be considered as one of the etiologies. The mean total symptom scores decreased in both treatment groups after the study period. There was a considerable reduction in the scores of physical, emotional, and functional symptoms in both groups. A marked reduction in emotional scores was observed in group I compared to group II in the post-treatment and follow-up assessments.
Conclusion: Epley’s manoeuvre is superior in relieving vertigo in patients with BPPV compared to Brandt Daroff’s exercise.

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Study of maternal and fetal outcome in COVID positive patients

TCMS-Special issue: Recent developments of medical and surgical research (2023), pp. 529 – 533 Open Access Full-Text PDF
Aprajita and Smita Krishnarao Bhat

Abstract:Background: Coronavirus disease 2019 [COVID 19] is caused by severe acute respiratory syndrome coronavirus 2[SARS-CoV-2] and was declared a global pandemic in March 2020. The impact of coronavirus disease 2019 on maternal and fetus health is unclear. We performed an observational study to determine the association between SARS-CoV-2 infection and adverse pregnancy outcomes, including preterm birth and stillbirth.
Materials and methods: Study is carried out in covid ward of the Department of Obstetrics and Gynaecology at Bharati Vidyapeeth Medical College and Hospital, Sangli. This is a retrospective study involving all pregnant patients admitted in the covid ward of our hospital from April 2021 to December 2021. Information regarding age, parity, condition of the patient at the time of admission to covid ward in terms of oxygen saturation, mode and time of delivery, outcome of pregnancy, fetal outcome and maternal morbidity and mortality were noted and analysed.
Results: From analysis of available data maternal hypoxia and fetal distress were the most common indications for caesarean section. Caesarean section accounted for 86.6% of all deliveries, successful vaginal delivery were reported in 2 out of 15 deliveries, rest 3 cases were reported as missed abortion and D&E was done.
Conclusion: Covid 19 infection in pregnancy may be associated with increased risk of caesarean section, preterm birth, increased morbidity and mortality.

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