Trends in Clinical and Medical Sciences
Special issue: Recent developments of medical and surgical research (2023), pp. 283 – 288
ISSN: 2791-0814 (online) 2791-0806 (Print)
DOI: 10.30538/psrp-tmcs2023.si-rdmsr038
ISSN: 2791-0814 (online) 2791-0806 (Print)
DOI: 10.30538/psrp-tmcs2023.si-rdmsr038
Study of prevalence of non-alcoholic fatty liver disease among pre-diabetic and diabetic patients
Nitin Wathore\(^{1,*}\), Datta Jude\(^{1}\) and Rahul Gaikwad\(^{1}\)
\(^{1}\) Assistant Professor, Department of Medicine, PCMC’s PGI & YCMH Pimpri, Pune, Maharashtra, India.
Correspondence should be addressed to Nitin Wathore at nitinuw88@gmail.com
Copyright © 2023 Nitin Wathore, Datta Jude and Rahul Gaikwad. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Received: December 8, 2022 – Accepted: April 14, 2023 – Published: April 17, 2023
Abstract
Background: Non-alcoholic fatty liver disease (NAFLD) is a common condition characterized by excess fat in the liver, which ranges from simple steatosis to steatohepatitis, cirrhosis, and hepatocellular carcinoma (HCC) in the absence of excessive alcohol intake. This study aimed to determine the prevalence of NAFLD among pre-diabetic and diabetic patients at a tertiary hospital.
Methods: This single-center, prospective, comparative, parallel-group, observational study included male and female patients between 30 and 70 years old who were either diabetic or pre-diabetic. A total of 600 patients with NAFLD were studied.
Results: Of the 200 diabetes cases studied, the prevalence of NAFLD was 52% (104 cases), while the prevalence of NAFLD among pre-diabetic cases was 45.5% (91 cases), and the prevalence of NAFLD among normal cases was 30.5% (61 cases). The prevalence of NAFLD was significant among females in all patient groups. Diabetic patients with NAFLD had a higher BMI and waist circumference than pre-diabetic and non-diabetic patients, and this difference was statistically significant. Diabetic patients with NAFLD also had higher Glycohemoglobin (%) and fasting glucose (mmol/L) than pre-diabetic and non-diabetic patients, and this difference was statistically significant. Liver function tests and other parameters such as total bilirubin, AST, ALT, GGT, LDL, HDL, total cholesterol, triglycerides, and platelet count were comparable in diabetic, pre-diabetic, and non-diabetic patients, and the difference was not statistically significant.
Conclusion: The prevalence of NAFLD among diabetic patients was 52%, while the prevalence of NAFLD among pre-diabetic cases was 45.5%. These findings highlight the importance of early screening and prevention strategies for patients with diabetes and pre-diabetes to reduce the burden of NAFLD.
Methods: This single-center, prospective, comparative, parallel-group, observational study included male and female patients between 30 and 70 years old who were either diabetic or pre-diabetic. A total of 600 patients with NAFLD were studied.
Results: Of the 200 diabetes cases studied, the prevalence of NAFLD was 52% (104 cases), while the prevalence of NAFLD among pre-diabetic cases was 45.5% (91 cases), and the prevalence of NAFLD among normal cases was 30.5% (61 cases). The prevalence of NAFLD was significant among females in all patient groups. Diabetic patients with NAFLD had a higher BMI and waist circumference than pre-diabetic and non-diabetic patients, and this difference was statistically significant. Diabetic patients with NAFLD also had higher Glycohemoglobin (%) and fasting glucose (mmol/L) than pre-diabetic and non-diabetic patients, and this difference was statistically significant. Liver function tests and other parameters such as total bilirubin, AST, ALT, GGT, LDL, HDL, total cholesterol, triglycerides, and platelet count were comparable in diabetic, pre-diabetic, and non-diabetic patients, and the difference was not statistically significant.
Conclusion: The prevalence of NAFLD among diabetic patients was 52%, while the prevalence of NAFLD among pre-diabetic cases was 45.5%. These findings highlight the importance of early screening and prevention strategies for patients with diabetes and pre-diabetes to reduce the burden of NAFLD.
Keywords:
NAFLD; Diabetic patients; Pre-diabetes; Metabolic syndrome.