Non-healing ulcers can cause significant health problems and impair quality of life. Standard treatment procedures have been found to be ineffective in curing such lesions. Autologous platelet-rich fibrin matrix (PRFM) has been cited in many research papers as an effective treatment for non-healing ulcers. This study aims to evaluate the efficacy of PRFM in treating chronic non-healing ulcers. A prospective study was conducted in patients with trophic ulcers due to Hansen’s disease or diabetes mellitus, traumatic ulcers, and venous ulcers, aged between 18-85 years. PRFM was applied to healthy ulcers at weekly intervals, repeated for a maximum of five sittings as per requirement. Photographs were taken before treatment and at every subsequent sitting, and area and volume were calculated at baseline and every subsequent sitting until closure was achieved. The results of the study will help to determine the efficacy, feasibility, and cost-effectiveness of PRFM in the treatment of non-healing ulcers.
