Volume 2019 Issue 1

Author(s): Muhammad Athar Abbasi1,2, Seong-Hui Eo1, Aziz- ur- Rehman2, Sabahat Zahra Siddiqui2, Yohan Han1, Seon-Mi Yu1, Song Ja Kim1, Mubashir Hassan1, Hussain Raza1, Syed Anan Ali Shah3, Sung-Yum Seo1
1College of Natural Sciences, Department of Biological Sciences, Kongju National University, Gongju, 32588, South Korea.
2Department of Chemistry, Government College University, Lahore-54000, Pakistan.
3Faculty of Pharmacy and Atta-ur-Rahman Institute for Natural Products Discovery (AuRIns), Level 9, FF3, Universiti Teknologi MARA, Puncak Alam Campus, 42300 Bandar Puncak Alam, Selangor Darul Ehsan, Malaysia.
Abstract:

Matrix metalloproteinases-2 and -9 (MMP-2/-9) are key tissue remodeling enzymes that have multiple overlapping activities critical for wound healing and tumor progression. In search of new anti-tumor agents, indole-oxadiazole containing butanamides (1-5) were evaluated with B16F10 mouse melanoma cells in this study. The results showed that compounds 1, 2 and 3 inhibited the cell proliferation in a considerable manner at concentrations ranging from 0-44M. The possible migration inhibitory effects of these melanoma cells were further evaluated through gelatinolytic activity of MMP-2 and MMP-9 secreted from B16F10 cells and it was inferred that compounds 1, 2 and 3 affected the expression and activity of these enzymes in a dose dependent manner while compound 1 can be regarded as promising anti-tumor agent.

Author(s): Aisha Shamim1, Zaheer Ahmad1, Sajid Mahmood2, Umair Ali2, Tariq Mahmood3, Zamir Ahmad Nizami4
1Department of Chemistry, University of Wah, Wah Cantt 47040, Pakistan.
2Department of Chemistry, Division of Science and Technology, University of Education, Township Campus, Lahore, Pakistan.
3Nano Sciences and Technology Department, National Centre for Physics, QAU, Islamabad 45320, Pakistan.
4Department of Chemistry, University of Sargodha,Sub Campus Bhakkar, Pakistan.
Abstract:

The under consideration study focuses on synthesis and characterization of Nickel oxide (NiO) nanoparticles. Nanosized Nickel oxide powder was successfully synthesized using a simple and low cast sol-gel method. This method is environment friendly requiring no expensive chemicals and is time saving. The sol-gel method was accompanied by the formation of precipitates which were dried and calcined at 550\(^{o}\)C to get nickel oxide nanoparticles. The synthesized nanopowder was characterized by X-ray diffraction (XRD), Scanning Electron Microscopy (SEM), and Energy Dispersive Spectroscopy (EDX).

Author(s): Farman ullah Khan1, Sajid Mahmood2, Zaheer Ahmad1, Tariq Mahmood3, Zamir Ahmad Nizami4
1Department of Chemistry, University of Wah, Wah Cantt 47040, Pakistan.
2Department of Chemistry , Division of Science and Technology, University of Education, Lahore 54000, Pakistan.
3Nano Sciences and Technology Department, National Centre for Physics, QAU, Islamabad 45320, Pakistan.
4Department of Chemistry, University of Sargodha,Sub Campus Bhakkar, Pakistan.
Abstract:

The graphene and graphene oxide are latest and advanced materials with wide applications in environment, medical applications, industries, defense applications. We have synthesized graphene oxide from graphite flakes by modifying Hummer method in which we used NaNO\(_{2}\) instead of NaNO\(_{3}\). Then we characterized our samples with X-Ray Diffractometry (XRD), Scanning-Electron Microscopy (SEM) and Fourier-Transform Infrared-Spectroscopy (FT-IR). These results confirmed the formation of graphene oxide also through this process. This graphene oxide can further be used for future applications in wastewater treatment and biomedical applications.

Author(s): Aziz- Ur- Rehman1, Muhammad Athar Abbasi1, Sabahat Zahra Siddiqui1, Shahid Rasool1, Sadia Jabeen1, Amar Masood Joyia1, Asma Salah-Ud-Din Gondal1
1Department of Chemistry, Government College University, Lahore-54000, Pakistan.
Abstract:

Sulfonamides are considered to be biologically active and an important class of pharmaceutical compounds. These constitute an important class of antimicrobials, antidiabetics, anticancer and diuretics. These were the first chemotherapeutic drugs introduced to the world but their rapidly developed resistance decreased their use. In the present work, N-(2/4-substitutedphenyl)-4-(substituted)benzenesulfonamide (3a-d) and N-(tetrahydrofuran-2-ylmethyl)-4-methylbenzenesulfonamide 3e were synthesized by the reaction of substituted aniline (1a-c) and tetrahydrofuran-2-ylmethanamine (1d) with substituted benzenesulfonyl chloride (2a-d) using 10% aqueous \(Na_{2}CO_{3}\) solution as a reaction medium. In the second step, the synthesized molecules 3a-e were allowed to react different alkyl/aralkyl halides (4a-j) to synthesize the target N-substituted compounds, 5a-z,aa,bb, using lithium hydride as an activator and N,N-dimethylformamide (DMF) as a reaction medium. All the synthesized compounds were characterized by using spectral techniques such as \(^{1}\)H-NMR, IR and EI-MS; and further examined for their anti-bacterial activities.