Introduction: Thyroid nodules are commonly encountered in clinical practice. The palpable thyroid nodules prevalence in the worldwide population ranges from 4 to 7%. The thyroid lesions are mostly benign (95%) and thyroid cancer is responsible for only 0.4% of all cancer deaths. The Bethesda System for Reporting thyroid Cytopathology (TBSRTC) was done in 2010. The liquid-based cytology (LBC) technique used in exfoliative cells and in non-gynecological aspiration like fine needle aspiration (FNA) samples. Liquid-based cytology (LBC) preparation is a way to improve and refine the fine-needle aspiration (FNA) samples of thyroid lesion. It achieves a diagnostic sensitivity as accurate as conventional preparations, especially for its excellent cell preservation and rapid fixation, lack of background which decrease the number of inadequate diagnoses.
Aims and Objectives: 1) To compare conventional and manual liquid-based cytology in thyroid lesion at tertiary care centre. 2) To find out if there is any significance increase in the positive cases which were negative on conventional smear. 3) Whenever possible correlate the histopathological finding with the Liquid Based Cytology results to make a more confirmed diagnosis.
Material and Methods: This is prospective conducted on 70 patients at Department of Pathology, Mahatma Gandhi Medical College and Maharaja Yeshwant Rao Hospital, Indore, Madhya Pradesh, India for duration of 2 years. Permission was obtained from the departmental scientific committee and the institutional ethical committee at the beginning of the study.
Results: With the help of above thesis work we have observed that manual LBC is also a relatively simple technique.
