Objective: To compare the efficacy of sublingual misoprostol tablet and intracervical dinoprostone gel for induction of labour in nulliparous postdated pregnancy and assess the maternal and fetal outcome after induction.
Methodology: It is a prospective randomized controlled study conducted over a period of 2 years (nov 2020 to nov 2022), in dept. of obstetrics and gynecology, mkcg mch. Out of 200 cases 100 cases were given sublingual misoprostol tablet (Group 1) and rest were given intracervical dinoprostone gel (Group 2). The efficacy of both the drugs were assessed by favorability of Bishop’s score at 24 hours, need of augmentation with oxytocin, drug administration to delivery interval, mode of delivery, APGAR score, NICU admission, maternal complication and number of failed induction, data was analyzed description statistics and chi square test.
Result: Mean Drug administration to delivery interval was shorter and significant (18. 53hours vs 20.42) hours, p-value 0.0018). Need for augmentation (48 vs 65, p-value 0.0125), failed induction rate (5 vs 11), post-delivery mean blood loss( 436.50mL vs 516 mL, p value- 0.0173) were significantly lower with misoprostol group. NICU admission was lower in dinoprostone group (7 vs 14).
Conclusion: Sublingual misoprostol tablet is efficacious in inducing labour, with shorter drug administration to induction interval, and higher vaginal delivery rate as compared to dinoprostone gel.
