Background and Aims: Diastolic dysfunction is the commoncondition with Subclinical Hypothyroidism and is reversible inmany cases after treatment. We aimed to investigate the responseof diastolic dysfunction to thyroid hormone replacement therapyin patients of Subclinical Hypothyroidism.
Methods: 100 newly diagnosed cases of SubclinicalHypothyroidism (78 females and 22 males) and age more than 18years were included. Diagnosis was made on the basis of history,clinical examination and thyroid function tests. Echocardiographywas performed in all and was repeated after 4-6 months inthose who had diastolic dysfunction. Distribution of Diastolicdysfunction among the involved cases and their response totreatment with L-thyroxine were studied.
Results: Out of 100 patients included in the study, 78 patients were female and 22 patients were males. Out of 78 female patients, 28 patients had grade-1 diastolic dysfunction and 50 patients did not have diastolic dysfunction. Out of 22 male patients, 08 patients had grade-1 diastolic dysfunction and 14 patients did not have diastolic dysfunction. With replacement therapy, 28 reverted backto the normal whereas one having grade 2 diastolic dysfunction(pseudonormal pattern) reverted to grade 1. One patient whohad grade 1 diastolic dysfunction (impaired relaxation) did notimprove. Pericardial effusion subsided in all 5 cases.
Conclusions: Echocardiography may be a useful tool formonitoring the response of diastolic dysfunction to thyroid hormonereplacement therapy in patients with Subclinical Hypothyroidism. Our findings suggest that Thyroid Hormone Replacement Therapymay reverse diastolic dysfunction in Subclinical Hypothyroidism.
