Nicotiana tabacum is rich with medicinal importance. The aim of the study is to isolate, purify and compare nicotine (3-[1-Methylpyrolidine-2 yl] pyridine) from different brands of cigarettes. Isolation is carried out by liquid-liquid extraction using ether as solvent. Crude nicotine samples are further purified with SPE (solid phase extraction) method. Nicotine crystals are complexed with zinc chloride (\(ZnCl_{2}\)). Fine and pure crystals of metal complexes are obtained with Nic-C and Nic-D. However, no complex formation is synthesized with Nic A and Nic-B due to impurities in the sample which is confirmed by thin layer chromatography. Antibacterial activity of the samples is carried out against different strains of bacteria which showed positive results for Nic-C and Nic-D. The outcomes of the study reveal that Zinc-Nicotine complexes can be used as therapeutic agents and anti-sickness agents in sickle cell disease.
Nanoparticles are nanosized clusters with dimensions less than 100nm. Nanoparticles are fabricated by physical, chemical, and biological methods. Physical and chemical methods are energy intensive and involve hazards of contaminations. Biological synthesis of nanoparticles is environment friendly, less toxic and cost effective process. Plants, microorganisms, and biomolecules are commonly exploited species for merging of nanoparticles in this method. In present work we synthesize Chromium oxide nanoparticles by biological method using fungal extract of Aspargillus Niger. The synthesized nanoparticles are characterized by XRD (X-Ray Diffraction), SEM (Scanning Electron Microscopy) and UV-Vis (Ultraviolet Visible) techniques.
Let \(\Omega\in{L}^{\infty}(\mathbb{R}^{n})\times{L^{2}(S^{n-1})}\) be a homogeneous function of degree zero. In this article, we obtain some boundedness of the parameterized Littlewood-Paley operators with variable kernels on weighted Herz spaces with variable exponent.
Topological indices collect information from the graph of molecule and help to predict properties of underlined molecule. Zagreb indices are among the most studied topological indices due to its applications in chemistry. In this report we compute first and second reversed Zagreb indices and first and second reversed Hyper Zagreb indices for \(Si_{2}C_{3}I[r,s]\) and \(Si_{2}C_{3}II[r,s]\). Moreover we also compute first and second reversed Zagreb polynomials and first and second reversed Hyper Zagreb polynomials for \(Si_{2}C_{3}I[r,s]\) and \(Si_{2}C_{3}II[r,s]\).
The objective of the present study was to investigate and compare the efficacy, physiochemical equivalence and purity of API’s of different brands of cetirizine 2HCl tablets (10mg) with that of multinational brands available in local market of Lahore, Pakistan. The present work also provides awareness to allergy patients about most effective local brands with reasonable prices, without any health risk. Spectrophotometric method was used for chemical assay, TLC technique was subjected for the purity of API’s and physiochemical parameters was employed i.e; weight variation, hardness, friability, thickness, disintegration time and dissolution study as well as price fluctuation in PK rupees. The results of all physiochemical parameters and chemical assay were found to be within limit and meet to the pharmacopeial standards. TLC technique was developed to check the quality and purity of API, all the active ingredients showed the similar \(R_{f}\)-values without any impurity (0.38-0.39). From the test results and plots, it was observed and concluded that an economical and quality products can be prescribed for allergy patients whether they are manufactured by the local or multinational pharmaceutical companies without any health risk.
