The present research studies the robust control of DC bus voltage in a proton-exchange membrane fuel cell (PEMFC)-fed power system using two-phase interleaved boost converter. The two-phase interleaved boost converter uses as a source two series-connected 6 kW PEMFC stacks that produce low-voltage DC source, which is converted to the stable 400V DC bus. The voltage control of the boost converter is realized by a simple proportional-integral voltage controller, which provides a duty-cycle signal for phase-shifted pulse-width modulation of the converter. The performance of the system is analyzed during variations of load demand, atmospheric pressure, and source/load disturbance. It is shown that the interleaved boost converter ensures the constant voltage level of the bus at 400V under step-changes of the load power and under decrease of the pressure from 1.0 bar to 0.3 bar. The decrease of the fuel cell voltage with increase of the load current and with decreasing of reactant pressure is compensated by adjusting the duty cycle of the converter and preventing the voltage collapse of the DC bus.