Coloring the arcs of biregular graphs was introduced with possible applications to industrial chemistry, molecular biology, cellular neuroscience, etc. Here, we deal with arc coloring in some non-bipartite graphs. In fact, for \(1<k\in\mathbb{Z}\), we find that the odd graph \(O_k\) has an arc factorization with colors \(0,1,\ldots,k\) such that the sum of colors of the two arcs of each edge equals \(k\). This is applied to analyzing the influence of such arc factorizations in recently constructed uniform 2-factors in \(O_k\) and in Hamilton cycles in \(O_k\) as well as in its double covering graph known as the middle-levels graph \(M_k\).
