The Ptolemy journal of Chemistry (PJC) (2618-0758 online, 2618-074X Print) formally known as Open Journal of Chemistry is a global research journal devoted to the publication of unique and brilliant research papers in all field of applied and experimental chemistry. To guarantee quick publication, editorial decisions on acceptance or otherwise are taken within 4 to 12 weeks (three months) of receipt of the paper. Accepted articles are instantly distributed online when they are prepared for publication. There is one volume containing two issues for each year. The issues will be published in June and December. The printed version will be published in December of each year. The journal will also consider Review, letters, Case Report, Short communications and Editorial Articles.
The objective of the present work was to develop and validate of an analytical method for the quantitative determination of Fexo. HCL and Pseudo. HCL in a combine tablet dosage form by \(UV-V\) is spectrophotometry and TLC. The main problem was to separate the two active ingredient from a single bilayered tablet because both the A.P.I’s were soluble in the same solvents. As media selection, distilled water and ethanol \((1:1)\) were used for Pseudo. HCl and methanol for Fexo. HCl, in which both the drugs were soluble and stable for a sufficient time. Both drugs were measured at \(220\)nm and \(247\)nm, where they showed maximum absorbance. Beer Lambert’s law was obeyed at concentration range \(4-14\) ppm and \(5-30\) ppm for Fexo. HCL and Pseudo HCL respectively. Fexo. HCl \((Y=0.0643x+0.9370)\) was measured with correlation coefficient \(r =0.9574\) and Pseudo. HCl \((Y=0.0843x+0.0219)\) with correlation coefficient \(r =0.9992\). The results of analysis have been validated statistically and recovery studies were carried out as \(99.29\%\pm 0.943\) and \(99.29\%\pm 0.941\) which were close to the assay value \(100.1\% \& 100.6 \%\). Precision of the method was measured which showed results for SD \((99.57 \% \;\;\& \;\;99. 51% )\) and \(\%\) RSD \((99.53 \%\;\; \&\;\; 99.54)\). The proposed method may be suitably applied for the analysis of Fexo. HCL and Pseudo.HCL in tablet pharmaceutical formulation for routine analysis.
