Our aim in this research note is to compare curcumin and clobetasol propionate in management of patients with oral lichen planus. Sixty- four patients of OLP were divided where 32 patients were put in group I in which patients received 0.1% triamcinolone and in group 2, 32 patients received 5% curcumin paste for 4 weeks. Measurement of the appearance score and severity of pain was done at baseline and at the end of 2 and 4 weeks. We found that complete remission in pain was seen in 30% in group 1 and 35% in group 2, good response in 28% in group 1 and 17% in group 2, poor response in 24% in group 1 and 25% in group 2 and no response in 18% in group 1 and 33% in group 2. A non- significant difference among good and no response was seen (P<0.05). Oral lichen planus is common inflammatory autoimmune disease. Curcumin in our study showed slightly better results than triamcinolone, hence suggesting that it can be used in patients with oral lichen planus.
The novel corona virus (COVID-19) outbreak declared as a global pandemic. Glucocorticoids are inexpensive, widely available, and have been shown to reduce mortality in hypoxemic patients with COVID-19. With increasing risk of new strains of covid virus infections and now the latest dreadful fungal infection Mucormycosis, the situation is becoming more and more devastating. Survival in mucormycosis depends on early diagnosis, alleviation of basic predisposing factors, aggressive debridement of necrotic tissues, and appropriate systemic antifungal agents.
Our main goal is to compare effect of ondansetron and ramosetron in attenuation of propofol-induced pain during induction of anaesthesia. A total of sixty subjects with American Society of Anesthesiologists (ASA) physical status (PS) 1 and 2, age ranging 18-60 years scheduled for various elective surgical procedures under general anaesthesia were included and were randomly divided into 2 groups. Group 1 received 4 mg of ondansetron and Group II received 0.3 mg of ramosetron. Mean age of patients in group 1 was 36.2 years and in group 2 was 36.0 years. There were 16 males and 14 females in group 1 and 17 males and 13 females in group 2. ASA grade I was seen in 20 in group 1 and 24 in group 2 and ASA grade II was seen in 10 in group 1 and 6 in group 2. A non- significant difference between both groups was seen (P> 0.05). Pain score 0 was observed in 14 in group 1 and 20 in group 2, score 1 in 9 in group 1 and 6 in group 2, score 2 in 4 in group 1 and 3 in group 2 and score 3 seen in 3 in group 1 and 1 in group 2. A significant difference between both groups was seen (P< 0.05). Ramosetron alone can be used to reduce the propofol-induced pain. Pre-treatment with IV ramosetron found to be effective as compared to ondansetron in preventing propofol-induced pain.
The aim of this paper is to compare single versus multiple gall stone disease in patients undergoing laparoscopic cholecystectomy. A total of one hundred and thirty patients (males- 52, females- 78) within age group 20-65 years presented with cholelithiasis were divided into 2 groups. Group 1 comprised of single stone patients and group II had multiple stones. Each group had 65 patients. Parameters compared were symptoms and operative findings between both groups, Analysis of results was carried with chi0 square test. Most common clinical symptoms found to be fever in both groups (87%- group 1, 90%- group 2). Other symptoms were dyspepsia seen in 25% and 30%, nausea/ vomiting in 45% and 38% in group 1 and 2 patients respectively. Females were commonly affected and maximum case were observed in age group 40-50 years. Multiple gall stones patients had more symptoms and prevalence of conversion to open surgery was more in these patients. Group 1 patients showed gall bladder distention in 56 and group 2 in 62 patients, gall bladder contraction was seen in 6 patients in group 1 and 3 in group 2, adhesions were exhibited by 11 patients in group 1 and 20 in group 2. 4 patients in group 2 converted to open surgery. Gangrenous gall bladder was seen in 1 in group 1 and 5 in group 2.
The aim of this paper is to compare different treatment modalities in management of plantar fasciitis. Forty- five patients with plantar fasciitis (males- 2- females- 20) were randomized into 3 groups. Group 1 patients received conventional treatment, group 2 patients received heat treatment with silicone heel pad and group 3 patients received active plantar fascia stretching with sham calf stretching. Patient was evaluated using foot function index (FFI) and the foot and ankle disability index (FADI). In group 1, foot function pre-intervention index score and post-intervention score was 68.2 and 43.5, in group 2 was 64.8 and 6.9 and in group 3 was 70.5 and 1.6 respectively. A significant difference was observed (P< 0.05). In group 1, pre-intervention foot and ankle disability score and post-intervention score was 61.5 and 76.4, in group 2 was 66.5 and 95.2 and in group 3 was 61.3 and 97.6 respectively. A significant difference was observed (P< 0.05). Active plantar fascia stretching with sham calf stretching exercise resulted in most significant improvement in FFI and FADI score followed by treatment with heat and silicone heel pad and conventional treatment.
