In this paper, new sufficient conditions are obtained for oscillation of second-order neutral delay differential equations of the form \(\frac{d}{dt} \Biggl[r(t) \frac{d}{dt} \biggl [x(t)+p(t)x(t-\tau)\biggr]\Biggr]+q(t)G\bigl(x(t-\sigma_1)\bigr)+v(t)H\bigl(x(t-\sigma_2)\bigr)=0, \;\; t \geq t_0,\) under the assumptions \(\int_{0}^{\infty}\frac{d\eta}{r(\eta)}=\infty\) and \(\int_{0}^{\infty}\frac{d\eta}{r(\eta)}<\infty\) for \(|p(t)|<+\infty\). Two illustrative examples are included.

This study investigate movements of molecule on the biological cell via the cell walls at any given time. Specifically, we examined the movement of a particle in tiling, i.e. in hexagonal and square tiling. The specific questions we posed includes (i) whether particles moves faster in hexagonal tiling or in square tiling (ii) whether the starting point of particles affect the movement toward attainment of stationary distribution. We employed the transitional probabilities and stationary distribution to derive expected passage time to state \(j\) from state \(i\), and the expected recurrence time to state \(i\) in both hexagonal and square tiling. We also employed aggregation of state symmetries to reduce the number of state spaces to overcome the problems (i.e. the difficulty to perform algebraic computation) associated with large transition matrix. This approach leads to formation of a new Markov chain \(X_t\) that retains the original Markov chains properties, i.e. by aggregation of states with the same stochastic behavior to the process. Graphical visualization for how fast the equilibrium is attained with different values of the probability parameter \(p\) in both tilings is also provided. Due to difficulties in obtaining some analytical results, numerical simulation were performed to obtains useful results like expected passage time and recurrence time.

The author considers a mathematical model of immunotherapy and anti-angiogenesis inhibitor therapy for cancer patients over a fixed time horizon. Disease dynamics are captured by a system of ODEs developed in [1], describing dynamics among host cells, cancer cells, endothelial cells, effector cells, and anti-angiogenesis. Existence, uniqueness, and characterization of optimal treatment profiles that minimize the tumor and drug usage, while maintaining healthy levels of effector and host cells are determined. A theoretical analysis is performed to characterize the optimal control. Numerical simulations are performed to illustrate optimal control profiles for a variety of different patients, each leading to different treatment protocols.

The objective of this paper is to investigate the existence and uniqueness theorem for stochastic partial differential equations with poisson jumps and delays. The existence of mild solutions of the problem is studied by using a different resolvent operator defined in [1] and fixed point theorem.

In this work, we study the small oscillations of a system formed by an elastic container with negligible density and a heavy barotropic gas (or a compressible fluid) filling the container. By means of an auxiliary problem, that requires a careful mathematical study, we deduce the problem to a problem for a gas only. From its variational formulation, we prove that is a classical vibration problem.

In this paper we define a new class of hyperholomorphic functions, which is known as \(F^{\alpha}_{G}(p,q,s)\) spaces. We characterize hyperholomorphic functions in \(F^{\alpha}_{G}(p,q,s)\) space in terms of the Hadamard gap in Quaternion analysis.

The effects of shear deformation and rotary inertia on the dynamics of anisotropic plates traversed by varying moving load resting on Vlasov foundation is investigated in this work. The problem is solved for concentrated loads with simply supported boundary conditions. An analytic solution based on the Galerkin’s method is used to reduce the fourth order partial differential equation into a system of coupled fourth order differential equation and a modification of the Struble’s technique and Laplace transforms are used to solve the resulting fourth order differential equation. Results obtained indicate that shear deformation and rotary inertia have significant effect on the dynamics of the anisotropic plate on the Vlasov foundation. Solutions are obtained for both the moving force and the moving mass problems. From the graphical results obtained, the amplitude of vibrations of the plate under moving mass is greater than that of the moving force and increasing the value of rotary inertia \({R_0}\) reduces the amplitude of vibration of the plate. increasing the mass ratio increases the amplitude of vibration of the plate.