Ptolemy Journal of Chemistry (PJC)

Matrix metalloproteinases-2 and -9 (MMP-2/-9) are key tissue remodeling enzymes that have multiple overlapping activities critical for wound healing and tumor progression. In search of new anti-tumor agents, indole-oxadiazole containing butanamides (1-5) were evaluated with B16F10 mouse melanoma cells in this study. The results showed that compounds 1, 2 and 3 inhibited the cell proliferation in a considerable manner at concentrations ranging from 0-44M. The possible migration inhibitory effects of these melanoma cells were further evaluated through gelatinolytic activity of MMP-2 and MMP-9 secreted from B16F10 cells and it was inferred that compounds 1, 2 and 3 affected the expression and activity of these enzymes in a dose dependent manner while compound 1 can be regarded as promising anti-tumor agent.

The under consideration study focuses on synthesis and characterization of Nickel oxide (NiO) nanoparticles. Nanosized Nickel oxide powder was successfully synthesized using a simple and low cast sol-gel method. This method is environment friendly requiring no expensive chemicals and is time saving. The sol-gel method was accompanied by the formation of precipitates which were dried and calcined at 550\(^{o}\)C to get nickel oxide nanoparticles. The synthesized nanopowder was characterized by X-ray diffraction (XRD), Scanning Electron Microscopy (SEM), and Energy Dispersive Spectroscopy (EDX).

The graphene and graphene oxide are latest and advanced materials with wide applications in environment, medical applications, industries, defense applications. We have synthesized graphene oxide from graphite flakes by modifying Hummer method in which we used NaNO\(_{2}\) instead of NaNO\(_{3}\). Then we characterized our samples with X-Ray Diffractometry (XRD), Scanning-Electron Microscopy (SEM) and Fourier-Transform Infrared-Spectroscopy (FT-IR). These results confirmed the formation of graphene oxide also through this process. This graphene oxide can further be used for future applications in wastewater treatment and biomedical applications.

Sulfonamides are considered to be biologically active and an important class of pharmaceutical compounds. These constitute an important class of antimicrobials, antidiabetics, anticancer and diuretics. These were the first chemotherapeutic drugs introduced to the world but their rapidly developed resistance decreased their use. In the present work, N-(2/4-substitutedphenyl)-4-(substituted)benzenesulfonamide (3a-d) and N-(tetrahydrofuran-2-ylmethyl)-4-methylbenzenesulfonamide 3e were synthesized by the reaction of substituted aniline (1a-c) and tetrahydrofuran-2-ylmethanamine (1d) with substituted benzenesulfonyl chloride (2a-d) using 10% aqueous \(Na_{2}CO_{3}\) solution as a reaction medium. In the second step, the synthesized molecules 3a-e were allowed to react different alkyl/aralkyl halides (4a-j) to synthesize the target N-substituted compounds, 5a-z,aa,bb, using lithium hydride as an activator and N,N-dimethylformamide (DMF) as a reaction medium. All the synthesized compounds were characterized by using spectral techniques such as \(^{1}\)H-NMR, IR and EI-MS; and further examined for their anti-bacterial activities.

The application of graph theory in chemical and molecular structure research far exceeds people’s expectations, and it has recently grown exponentially. In the molecular graph, atoms are represented by vertices and bonded by edges. In this report, we study the M-polynomial of line graph of \(HAC_{5}C_{6}C_{7}[p,q]\) and recover many degree-based topological indices from it.

In this paper we aim to compute some Zagreb type polynomials of Möbius Ladder. Moreover we compute redefined Zagreb indices of Möbius Ladder.

The application of graph theory in chemical and molecular structure research far exceeds people’s expectations, and it has recently grown exponentially. In the molecular graph, atoms are represented by vertices and bonded by edges. In this report, we study the Zagreb-polynomials of line graph of \(HAC_{5}C_{6}C_{7}[p,q]\) and compute some degree-based topological indices from it.

In this work we have described the synthesis of Zinc Oxide nanoparticles through chemical and biological methods. For biological synthesis Aspargillus niger was used. The product obtained was characterized through different analytical techniques like XRD, SEM and EDX. The obtained results were matched with the literature. It was confirmed that the Zinc Oxide nanoparticles can also be prepared from Aspargillus niger.Which may be more ecofriendly and economical compared to other commonly used methods.

Topological indices are numerical numbers associated with a graph that helps to predict many properties of underlined graph. In this paper we aim to compute multiplicative topological indices of Circulant graph.

The objective of the present work was to develop and validate of an analytical method for the quantitative determination of Fexo. HCL and Pseudo. HCL in a combine tablet dosage form by \(UV-V\) is spectrophotometry and TLC. The main problem was to separate the two active ingredient from a single bilayered tablet because both the A.P.I’s were soluble in the same solvents. As media selection, distilled water and ethanol \((1:1)\) were used for Pseudo. HCl and methanol for Fexo. HCl, in which both the drugs were soluble and stable for a sufficient time. Both drugs were measured at \(220\)nm and \(247\)nm, where they showed maximum absorbance. Beer Lambert’s law was obeyed at concentration range \(4-14\) ppm and \(5-30\) ppm for Fexo. HCL and Pseudo HCL respectively. Fexo. HCl \((Y=0.0643x+0.9370)\) was measured with correlation coefficient \(r =0.9574\) and Pseudo. HCl \((Y=0.0843x+0.0219)\) with correlation coefficient \(r =0.9992\). The results of analysis have been validated statistically and recovery studies were carried out as \(99.29\%\pm 0.943\) and \(99.29\%\pm 0.941\) which were close to the assay value \(100.1\% \& 100.6 \%\). Precision of the method was measured which showed results for SD \((99.57 \% \;\;\& \;\;99. 51% )\) and \(\%\) RSD \((99.53 \%\;\; \&\;\; 99.54)\). The proposed method may be suitably applied for the analysis of Fexo. HCL and Pseudo.HCL in tablet pharmaceutical formulation for routine analysis.